Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 10 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
Top Medical Research Studies
8
Fucoidan's effects on breast cancer
We examined the effects of Fucoidan, a component from seaweed, on human breast cancer cells known as MCF-7. Our findings showed that Fucoidan significantly reduced the number of viable cancer cells in a dose-dependent way.
It led to G1 phase cell cycle arrest and increased apoptosis, which is the process of programmed cell death. These changes involved various molecular mechanisms, including the regulation of specific genes and increased production of reactive oxygen species.
Overall, our study suggests that Fucoidan has potential as a treatment for breast cancer through its ability to halt cell growth and promote cancer cell death.
It led to G1 phase cell cycle arrest and increased apoptosis, which is the process of programmed cell death. These changes involved various molecular mechanisms, including the regulation of specific genes and increased production of reactive oxygen species.
Overall, our study suggests that Fucoidan has potential as a treatment for breast cancer through its ability to halt cell growth and promote cancer cell death.
Read More
8
Sulfated fucans effective in cancer
We investigated how sulfated polysaccharides from Laminaria saccharina, a type of brown seaweed, might affect breast cancer and other conditions. Our experiments showed that the L.s.-1.25 fraction of these polysaccharides holds significant potential for reducing tumor growth and inhibiting cancer cell adhesion.
In contrast, another fraction, L.s.-1.0, displayed less effectiveness. The L.s.-1.25 fraction showed strong anti-inflammatory, angiogenic, and anticoagulant properties, crucial for its role against cancer. Overall, while we found promising results, specific polysaccharides appear more effective than others.
In contrast, another fraction, L.s.-1.0, displayed less effectiveness. The L.s.-1.25 fraction showed strong anti-inflammatory, angiogenic, and anticoagulant properties, crucial for its role against cancer. Overall, while we found promising results, specific polysaccharides appear more effective than others.
Read More
7
We investigated the effects of fucoidan, a polysaccharide derived from Laminaria japonica, on triple-negative breast cancer (TNBC). Our findings revealed that fucoidan has a modest ability to slow down the growth of TNBC cells.
It significantly reduced their ability to move and invade, and interfered with critical signaling pathways associated with cancer growth. In animal studies, fucoidan also showed potential by inhibiting blood vessel formation, which is essential for tumor growth. Overall, we see promising evidence that fucoidan might combat TNBC invasiveness and proangiogenesis.
It significantly reduced their ability to move and invade, and interfered with critical signaling pathways associated with cancer growth. In animal studies, fucoidan also showed potential by inhibiting blood vessel formation, which is essential for tumor growth. Overall, we see promising evidence that fucoidan might combat TNBC invasiveness and proangiogenesis.
Read More
Most Useful Reviews
9
Breast pain relief
1 people found this helpful
After taking this with NOW's evening primrose oil, my breast pain disappeared completely. It's as if I never had the pain, and I had forgotten it was ever a symptom.
Read More
9
Helped breast condition
This iodine supplement has helped significantly with my fibrocystic breasts. I ordered it years ago and experienced a great improvement. It has no taste and I find it very good quality.
Read More
7.5
Clarified brain fog
9 people found this helpful
I have hypothyroidism and understand brain fog well. This iodine is the only one that has provided noticeable results; neither kelp nor iodoral clarified my thinking as this has. It also alleviated my fibrocystic breast disease symptoms; the cysts became smaller.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
- All Researches
9.5
We set out to explore the effectiveness of iodine treatment in breast cancer, specifically through a unique approach called sonodynamic therapy (SDT). This involved using a specialized conjugate that combines a cyanine dye with the antibody trastuzumab, targeting HER2+ breast cancer cells in a mouse model.
Our findings demonstrated that a single dose of iodinated heptamethine cyanine, followed by sonication, led to significant tumor growth suppression. In fact, it achieved a remarkable 3.5-fold reduction in tumor volume within 45 days and was found to be significantly more effective than the non-iodinated version of the treatment.
Additionally, the iodinated variant outperformed traditional photodynamic therapy, highlighting the potential of utilizing iodine in combination with SDT. This treatment option showed no detectable toxicity to surrounding healthy tissues, making it a promising candidate for targeted cancer treatment. Overall, our study indicates that iodine plays a crucial role in enhancing the effectiveness of sonodynamic therapy for breast cancer treatment, paving the way for future research in this area.
Our findings demonstrated that a single dose of iodinated heptamethine cyanine, followed by sonication, led to significant tumor growth suppression. In fact, it achieved a remarkable 3.5-fold reduction in tumor volume within 45 days and was found to be significantly more effective than the non-iodinated version of the treatment.
Additionally, the iodinated variant outperformed traditional photodynamic therapy, highlighting the potential of utilizing iodine in combination with SDT. This treatment option showed no detectable toxicity to surrounding healthy tissues, making it a promising candidate for targeted cancer treatment. Overall, our study indicates that iodine plays a crucial role in enhancing the effectiveness of sonodynamic therapy for breast cancer treatment, paving the way for future research in this area.
Read More
8
Limited benefits for breast cancer
We investigated the anticancer potential of a modified polysaccharide derived from the brown alga Saccharina cichorioides. This carboxymethylated derivative, known as ScLCM, was tested on breast cancer cells (T-47D) alongside other cancer types.
While ScLCM showed strong anticancer and anti-invasive effects on certain cell lines, it was most effective against melanoma cells rather than breast cancer.
Our findings suggest that while there may be some benefits, ScLCM did not demonstrate significant improvements specifically for breast cancer viability and invasion compared to other types.
While ScLCM showed strong anticancer and anti-invasive effects on certain cell lines, it was most effective against melanoma cells rather than breast cancer.
Our findings suggest that while there may be some benefits, ScLCM did not demonstrate significant improvements specifically for breast cancer viability and invasion compared to other types.
Read More
8
We explored the potential of edible marine macroalgae to support human health, especially in relation to breast cancer.
By analyzing lipid extracts from various algae, we discovered that some possess antioxidant and anti-inflammatory properties.
Interestingly, specific algae showed strong effects in inhibiting cancer cell activity. However, the effects were varied and species-specific.
While our findings suggest a promising avenue for further research, we did not find universally effective results in treating breast cancer.
By analyzing lipid extracts from various algae, we discovered that some possess antioxidant and anti-inflammatory properties.
Interestingly, specific algae showed strong effects in inhibiting cancer cell activity. However, the effects were varied and species-specific.
While our findings suggest a promising avenue for further research, we did not find universally effective results in treating breast cancer.
Read More
8
We observed that fucoidan, a natural substance derived from kelp, demonstrated potential in slowing down breast cancer by affecting blood vessel growth. In our study, we evaluated its impact on tube formation in cell cultures and its effect when tested in chicken embryos with and without tumors.
The results highlighted how fucoidan could disrupt the development of new blood vessels and reduce tumor sizes. However, it’s important to note that while fucoidan impacted certain growth factors, it did not significantly lower vascular endothelial growth factor (VEGF) levels. Overall, fucoidan appears to be a promising natural treatment option for breast cancer.
The results highlighted how fucoidan could disrupt the development of new blood vessels and reduce tumor sizes. However, it’s important to note that while fucoidan impacted certain growth factors, it did not significantly lower vascular endothelial growth factor (VEGF) levels. Overall, fucoidan appears to be a promising natural treatment option for breast cancer.
Read More
8
Fucoidan's effects on breast cancer
We examined the effects of Fucoidan, a component from seaweed, on human breast cancer cells known as MCF-7. Our findings showed that Fucoidan significantly reduced the number of viable cancer cells in a dose-dependent way.
It led to G1 phase cell cycle arrest and increased apoptosis, which is the process of programmed cell death. These changes involved various molecular mechanisms, including the regulation of specific genes and increased production of reactive oxygen species.
Overall, our study suggests that Fucoidan has potential as a treatment for breast cancer through its ability to halt cell growth and promote cancer cell death.
It led to G1 phase cell cycle arrest and increased apoptosis, which is the process of programmed cell death. These changes involved various molecular mechanisms, including the regulation of specific genes and increased production of reactive oxygen species.
Overall, our study suggests that Fucoidan has potential as a treatment for breast cancer through its ability to halt cell growth and promote cancer cell death.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Breast pain relief
1 people found this helpful
After taking this with NOW's evening primrose oil, my breast pain disappeared completely. It's as if I never had the pain, and I had forgotten it was ever a symptom.
Read More
9
Helped breast condition
This iodine supplement has helped significantly with my fibrocystic breasts. I ordered it years ago and experienced a great improvement. It has no taste and I find it very good quality.
Read More
7.5
Clarified brain fog
9 people found this helpful
I have hypothyroidism and understand brain fog well. This iodine is the only one that has provided noticeable results; neither kelp nor iodoral clarified my thinking as this has. It also alleviated my fibrocystic breast disease symptoms; the cysts became smaller.
Read More
7.5
Remarkable improvement
8 people found this helpful
I had very sore fibrocystic breasts, but after taking 2000mcg of iodine daily and quitting coffee, I’m now 95% better. My doctor dismissed the pain as non-cancerous, but my own research helped me find relief.
Read More
9
Fights breast cancer
4 people found this helpful
If you're feeling low, consider adding iodine and vitamin D3; they can energise your thyroid. Iodine is vital in combating potential breast cancer, especially if you're genetically predisposed. LifeExtension is a trusted brand among health professionals.
Read More
Frequently Asked Questions
7.5
Remarkable improvement
8 people found this helpful
I had very sore fibrocystic breasts, but after taking 2000mcg of iodine daily and quitting coffee, I’m now 95% better. My doctor dismissed the pain as non-cancerous, but my own research helped me find relief.
5
Reduced breast pain
2 people found this helpful
Iodine should be taken with selenium, vitamin D, K, and omega-3 for optimal effect. This product worked well; after two months, my painful breasts before menstruation gradually improved, and I felt excellent with no side effects.
7.5
Softened fibroids
1 people found this helpful
I'm taking this for breast fibroids and believe in the power of natural healing. After my first bottle, my breasts felt softer, and I couldn't feel the fibroids. I restarted after a break, hoping to replicate the initial success.
9
Breast pain relief
1 people found this helpful
After taking this with NOW's evening primrose oil, my breast pain disappeared completely. It's as if I never had the pain, and I had forgotten it was ever a symptom.
9
Helped breast condition
This iodine supplement has helped significantly with my fibrocystic breasts. I ordered it years ago and experienced a great improvement. It has no taste and I find it very good quality.
7.5
Clarified brain fog
9 people found this helpful
I have hypothyroidism and understand brain fog well. This iodine is the only one that has provided noticeable results; neither kelp nor iodoral clarified my thinking as this has. It also alleviated my fibrocystic breast disease symptoms; the cysts became smaller.
7.5
Tumour growth slowdown
1 people found this helpful
This supplement has helped me take care of my breast health by slowing down tumour growth. I feel the positive effects, and my cycle discomfort has lessened. The capsules are small, the packaging is good, and the quality is high.
9
Fights breast cancer
4 people found this helpful
If you're feeling low, consider adding iodine and vitamin D3; they can energise your thyroid. Iodine is vital in combating potential breast cancer, especially if you're genetically predisposed. LifeExtension is a trusted brand among health professionals.
7
We examined the effects of fucoidan from kelp on triple-negative breast cancer cells. Our experiments revealed that fucoidan exhibits some ability to kill cancer cells and promote apoptosis, a process that encourages cell death. While it shows promise, the amount needed for effectiveness is considerably higher than traditional treatments.
We also noticed that fucoidan works through various mechanisms to induce apoptosis, indicating its potential in cancer therapy. Nevertheless, further research is essential to fully understand its effectiveness and its broader applications in treating breast cancer.
We also noticed that fucoidan works through various mechanisms to induce apoptosis, indicating its potential in cancer therapy. Nevertheless, further research is essential to fully understand its effectiveness and its broader applications in treating breast cancer.
7
We investigated the effects of fucoidan, a polysaccharide derived from Laminaria japonica, on triple-negative breast cancer (TNBC). Our findings revealed that fucoidan has a modest ability to slow down the growth of TNBC cells.
It significantly reduced their ability to move and invade, and interfered with critical signaling pathways associated with cancer growth. In animal studies, fucoidan also showed potential by inhibiting blood vessel formation, which is essential for tumor growth. Overall, we see promising evidence that fucoidan might combat TNBC invasiveness and proangiogenesis.
It significantly reduced their ability to move and invade, and interfered with critical signaling pathways associated with cancer growth. In animal studies, fucoidan also showed potential by inhibiting blood vessel formation, which is essential for tumor growth. Overall, we see promising evidence that fucoidan might combat TNBC invasiveness and proangiogenesis.
8
We observed that fucoidan, a natural substance derived from kelp, demonstrated potential in slowing down breast cancer by affecting blood vessel growth. In our study, we evaluated its impact on tube formation in cell cultures and its effect when tested in chicken embryos with and without tumors.
The results highlighted how fucoidan could disrupt the development of new blood vessels and reduce tumor sizes. However, it’s important to note that while fucoidan impacted certain growth factors, it did not significantly lower vascular endothelial growth factor (VEGF) levels. Overall, fucoidan appears to be a promising natural treatment option for breast cancer.
The results highlighted how fucoidan could disrupt the development of new blood vessels and reduce tumor sizes. However, it’s important to note that while fucoidan impacted certain growth factors, it did not significantly lower vascular endothelial growth factor (VEGF) levels. Overall, fucoidan appears to be a promising natural treatment option for breast cancer.
7
Kelp shows potential in cancer research
We assessed the effects of sulfated polysaccharides from marine algae on breast cancer. Focusing on laminaria, gelidium, and porphyra species, we found that these polysaccharides exhibit antioxidant and immune-boosting properties.
Specifically, the polysaccharides from Laminaria ochroleuca showed notable activity against human breast adenocarcinoma cells. However, while they had potential, the study did not indicate significant benefits for actual breast cancer treatment beyond laboratory results.
Overall, kelp could be a valuable addition to cancer research, particularly in enhancing immune response.
Specifically, the polysaccharides from Laminaria ochroleuca showed notable activity against human breast adenocarcinoma cells. However, while they had potential, the study did not indicate significant benefits for actual breast cancer treatment beyond laboratory results.
Overall, kelp could be a valuable addition to cancer research, particularly in enhancing immune response.
8
We explored the potential of edible marine macroalgae to support human health, especially in relation to breast cancer.
By analyzing lipid extracts from various algae, we discovered that some possess antioxidant and anti-inflammatory properties.
Interestingly, specific algae showed strong effects in inhibiting cancer cell activity. However, the effects were varied and species-specific.
While our findings suggest a promising avenue for further research, we did not find universally effective results in treating breast cancer.
By analyzing lipid extracts from various algae, we discovered that some possess antioxidant and anti-inflammatory properties.
Interestingly, specific algae showed strong effects in inhibiting cancer cell activity. However, the effects were varied and species-specific.
While our findings suggest a promising avenue for further research, we did not find universally effective results in treating breast cancer.
7
We explored how the brown seaweed, Fucus vesiculosus, affects breast cancer and other female cancers. Using several methods, we found that the extract inhibits estrogen receptor activation and promotes cell death in cancer cell lines, regardless of whether they relied on estrogen or not. This suggests it has broader anti-tumor benefits. Importantly, the study highlights that Fucus vesiculosus could contribute to new treatments, showing promise as a natural anti-cancer agent.
References
- Cruz Riquelme RT, Colona-Vallejos EH, Alzamora-Gonzales L, Condori Macuri RM. Fucoidan from Induces Apoptosis through Caspase Dependent and Caspase-Independent Activation in 4T1 Breast Adenocarcinoma In Vitro. Mar Drugs. 2024;22. doi:10.3390/md22060251
- Malyarenko OS, Usoltseva RV, Rasin AB, Ermakova SP. The carboxymethylated derivative of laminaran from brown alga Saccharina cichorioides: Structure, anticancer and anti-invasive activities in 3D cell culture. Int J Biol Macromol. 2023;226:803. doi:10.1016/j.ijbiomac.2022.11.247
- Lopes D, Melo T, Rey F, Meneses J, Monteiro FL, et al. Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications. Molecules. 2020;25. doi:10.3390/molecules25173883
- Hsu WJ, Lin MH, Kuo TC, Chou CM, Mi FL, et al. Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells. Int J Biol Macromol. 2020;149:600. doi:10.1016/j.ijbiomac.2020.01.256
- Oliveira C, Granja S, Neves NM, Reis RL, Baltazar F, et al. Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo. Carbohydr Polym. 2019;223:115034. doi:10.1016/j.carbpol.2019.115034
- Abdala Díaz RT, Casas Arrojo V, Arrojo Agudo MA, Cárdenas C, Dobretsov S, et al. Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum. Mar Biotechnol (NY). 2019;21:577. doi:10.1007/s10126-019-09905-x
- Burney M, Mathew L, Gaikwad A, Nugent EK, Gonzalez AO, et al. Evaluation Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus in Combination With Anticancer Drugs in Human Cancer Orthotopic Mouse Models. Integr Cancer Ther. 2018;17:755. doi:10.1177/1534735417740631
- Zhang J, Riby JE, Conde L, Grizzle WE, Cui X, et al. A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines. BMC Complement Altern Med. 2016;16:151. doi:10.1186/s12906-016-1129-6
- Banafa AM, Roshan S, Liu YY, Chen HJ, Chen MJ, et al. Fucoidan induces G1 phase arrest and apoptosis through caspases-dependent pathway and ROS induction in human breast cancer MCF-7 cells. J Huazhong Univ Sci Technolog Med Sci. 2013;33:717. doi:10.1007/s11596-013-1186-8
- Croci DO, Cumashi A, Ushakova NA, Preobrazhenskaya ME, Piccoli A, et al. Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from Laminaria saccharina brown seaweed. PLoS One. 2011;6:e17283. doi:10.1371/journal.pone.0017283
- Maruyama H, Watanabe K, Yamamoto I. Effect of dietary kelp on lipid peroxidation and glutathione peroxidase activity in livers of rats given breast carcinogen DMBA. Nutr Cancer. 1991;15:221.
- Zhang M, Yang Y, Xu Y, Wang J, Li S. Iodinated Copper-Cysteamine Nanoparticles as Radiosensitizers for Tumor Radiotherapy. Pharmaceutics. 2025;17. doi:10.3390/pharmaceutics17020149
- Muchtaridi M, Nurhidayah W, Fakih TM, Kannaka K, Suzuki H, et al. Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation. Drug Des Devel Ther. 2024;18:4511. doi:10.2147/DDDT.S479447
- Kobzev D, Semenova O, Aviel-Ronen S, Kulyk O, Carmieli R, et al. Sonodynamic Therapy for HER2+ Breast Cancer with Iodinated Heptamethine Cyanine-Trastuzumab Conjugate. Int J Mol Sci. 2024;25. doi:10.3390/ijms251810137
- Žatecký J, Heralt Z, Sekret D, Sehnálková E, Peteja M. Breast cancer localization by iodine seed 125I vs. wire- -guided localization - retrospective case-control study. Rozhl Chir. 2024;103:263. doi:10.48095/ccrvch2024263
